TEI-REX

Targeted Evaluation of Ionizing Radiation Exposure
TEI-REX

Intelligence Value

The TEI-REX program aims to establish novel approaches for evaluation of individuals or organisms exposed to low-dose ionizing radiation or biodosimetry. This will be accomplished through analysis of samples collected minimally or non-invasively, to include hair, skin, sweat, and saliva. These approaches will enable improved characterization and quantification of the exposure event and environment.

Summary

The TEI-REX program aims to enable methods for non-invasive, lower-dose evaluation of biological materials (i.e. low-dose biodosimetry). Current biodosimetry approaches suffer from a number of constraints, such as the need for invasive and/or serially collected samples, a dependence on transient markers, a focus on high-dose and high-throughput triage, and limited effective sample collection windows. The TEI-REX program will target research into robust and quantifiable biomarkers to overcome these limitations.

The TEI-REX program is anticipated to begin in Q3 FY22 and will be a 3.5- year effort investigating non-transient biomarkers that inform towards assessment of ionizing radiation exposure. Signatures detectable within 25 days and greater than 90 days post-exposure are expected to be identified.The program will initially focus on robust biomarkers associated with higher dose exposures while driving research towards lower-dose marker discovery. At the end of the program, viable biomarkers and biodosimetry models are expected to exhibit a high degree of precision and accuracy when tested against partner-informed real-world simulants and samples. TEI-REX capabilities will enhance IC and U.S. Government ability to investigate exposure events, enable counter proliferation efforts, and ensure compliance with established dosimetry protocols.

 

 TEI REX Slick Sheet Graphic v3.1 01

Proposers' Day Information:

TEI-REX Proposers' Day Briefing

TEI-REX Proposers' Day Technical Information

Sam.Gov Reference


Contact Information

Program Manager

Dr. Michael Patterson

Research Area(s)

Biodosimetry, Health Physics, Radiation Physics, Biomarker discovery, Ionizing Radiation, Low-dose Radiation, Analytical Biochemistry

Broad Agency Announcement (BAA)

Solicitation Status

CLOSED

Proposers' Day Date

September 29, 2021

BAA Release Date

October 19, 2021

Proposal Due Date

December 13, 2021

Program Summary

Testing and Evaluation Partners

  • Lawrence Berkeley National Laboratory
  • Los Alamos National Laboratory

Prime Performers

  • University of Washington
  • The Ohio State University
  • Signature Science, LLC
  • Areté Associates