FELIX

Finding Engineering-Linked Indicators
FELIX

Intelligence Value

The FELIX program aims to augment and improve current biodetection and biosurveillance capabilities by developing new computational and experimental tools for detection of engineered biological systems.

Summary

New biotechnologies have enabled the development of diverse biological systems, with potential benefits ranging from new vaccines to improved crops. Genome editing tools have made biological engineering more accessible, convenient, and economical. However, these tools could be misused -- accidentally or deliberately -- to adversely affect public health, the economy, and national security.

Current methods for detecting signs of biological engineering are typically costly, slow, and capable of detecting only a subset of all possible genetic modifications. The FELIX program is developing new computational and experimental tools and methods to improve and augment existing detection capabilities. Designed to work across a range of biological organisms that may be found in complex, multi-species environments, FELIX tools and methods can provide early alerts to the presence of engineered organisms and help expedite appropriate responses, thereby avoiding adverse consequences. The program’s achievements since its inception in June 2018 include:

Accomplishments

  • Proof-of-concept living biosensors to detect engineering markers
  • Detection of engineering signatures at the single-cell level
  • Detection of known signatures in a 1:100,000 ratio of target: background species
  • Extensive training data sets for machine learning algorithms

Related Publications

To access FELIX program-related publications, please visit Google Scholar.


COVID-19 Related Research

Contact Information

Program Manager

Dr. David Markowitz

Contracting Office Address

Office of the Director of National Intelligence

Intelligence Advanced Research Projects Activity

Washington, DC 20511

Research Area(s)

Bioinformatics, Biological detection, Evolutionary biology, Genome editing, Synthetic biology, Systems biology

Broad Agency Announcement (BAA)

Link(s) to BAA

FELIX BAA

Solicitation Status

CLOSED

BAA Release Date

August 31, 2017

BAA Question Period

August 31, 2017 — September 18, 2017

Proposal Due Date

Monday, 16 October 2017

Program Summary

Testing and Evaluation Partners

  • Argonne National Laboratory
  • Lawrence Berkeley National Laboratory 
  • Pacific Northwest National Laboratory 
  • United States Department of Agriculture-National Wildlife Research Center

Prime Performers

  • Broad Institute of the Massachusetts Institute of Technology and Harvard University
  • Ginkgo Bioworks Inc.
  • Harvard University Wyss Institute
  • Noblis Inc.
  • The Charles Stark Draper Laboratory Inc.
  • Raytheon BBN Technologies Corporation

Additional Information